Can you really not draw a distinction between appspot and google.com? They run googleusercontent.com to maintain that separation for Google Cache, after all.
No, per the linked check-in, the Egyptian govt would have to block OWSCensorshipConfigurationFrontingHost, which is "https://google.com". That is the domain looked up in DNS and included in the TLS Certificate's SNI field. These are the only domains that are sent plain-text.
"signal-reflector-meek.appspot.com" domain only shows up in the HTTP "Host" header, which is TLS encrypted, and thus not visible to the censors.
At brute force they will do as Turkey has done with YouTube, and order the ISPs to null route entire /20 to /16 sized pieces of the internet belonging to YouTube, etc. Same with appspot.
In most cases you could, but due to how google implements TLS termination, google ignores the SNI domain when considering what content to send, it only pays attention to the host header.